DETAILED NOTES ON PAIN KILLERS

Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (title Beforehand made use of: bishydroxycoumarin) and causes a lower in anticoagulant action as measured through the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in elevated metabolism and lessened anticoagulant reaction of oral anticoagulants (e